On December 9th, 1968, Stanford Research Institute scientist Douglas Engelbart demonstrated his unique invention–the computer mouse–for the first time in public. It took another decade and a half for it to catch on, but once it did, computing was never the same. And today, it’s hard to imagine using a desktop or laptop computer without a mouse (or one of its latter-day substitutes such as the touchpad). In celebration of the anniversary, here’s a gallery of some of the mightiest mice of the last four decades.