Lance Armstrong (seven-time Tour de France champion, cancer activist)

@lancearmstrong is often a man of a man of few words, even by Twitter standards. But cut the guy some slack: His stuff is engaging and real, and he tweets from TwitterBerry, which means he’s tapping his missives out on a BlackBerry. (Brownie points: He’s been known to post images via Twitpic.) If he chooses to pursue an eighth Tour de France trophy, it would be amazing if he found time to tweet from the road.