The 1993 “Microsoft Mouse 2.0” must have been one of the best-selling pointing devices of all time–I still see them faithfully in service fifteen years later. But for southpaws such as me, its “ergonomic” design was a curse: It was artfully sculpted to fit…your right hand. (I once had a Microsoft product manager cheerfully tell me that it was a good fit for lefties, too–as long as they switched hands to use it.) It started a trend towards non-ambidextrous design which continues, I’m sorry to say, to this day. (Image from GUIdebook.)